Antibodies from monkeys show promise against Covid variants

The team at the Scripps Research Institute in California identified antibodies from rhesus macaque monkeys that are effective against several different SARS-CoV-2 variants as well as other SARS viruses such as SARS-CoV-1, a highly lethal virus. Is. outbreak in 2003

They found that these neutralizing antibodies recognize a viral spike region that is relatively conserved, meaning it is present in many different SARS viruses and is therefore less likely to mutate over time.

The findings, published in Science Translational Medicine, showed that some animals are surprisingly more capable of making these types of “pan-SARS virus” antibodies than humans, giving scientists clues about how to make better vaccines. .

Senior author Rais Andrabi, an investigator in the Department of Immunology, said, “If we can design vaccines that elicit the same broad responses seen in this study, these treatments could enable broader protection against viruses and forms of anxiety.” Huh.” Microbiology.

In the study, rhesus macaque monkeys were immunized with the SARS-CoV-2 spike protein — the virus’s exterior that allows it to penetrate and infect host cells.

Two shots were administered, similar to a similar strategy used with currently available mRNA vaccines in humans. Unlike these vaccines, however, macaques were shown to have a broad neutralizing antibody response against the virus—including variants such as Omicron.

Exploring the antibody structures, the team found that these antibodies recognize a conserved region at the edge of the site where the spike protein binds to host cells, called the angiotensin converting enzyme 2 (ACE2) receptor binding site. This differs from the region where most human antibodies target, which overlaps more with the ACE2 receptor binding site and is more variable to change.

“The antibody structures reveal a critical region for many SARS-related viruses. This region has rarely been targeted by human antibodies to date and suggests additional strategies that our immune system can use to target this particular region.” virus,” said Ian Wilson, D.Phil, professor at the Institute.

In addition, the team said it’s important to note that the macaque’s gene coding for these broad neutralizing antibodies — known as IgHV3-73 — is not the same in humans. The major immune response in humans is related to the IGHV3-53 gene, which generates a potent but more narrow neutralizing antibody response.

However, scientists say the discovery opens the door to rationally designed and engineered vaccines or vaccine-assisted combinations that offer more comprehensive protection against SARS-CoV-2 and its many forms.

“According to our study, macaques have an antibody gene that gives them greater protection from the SARS virus. This observation teaches us that studying the effects of a vaccine in monkeys can take us only so far, but our It also reveals a new target for vaccine efforts that we may be able to exploit by advanced protein design strategies,” said Dennis Burton, co-senior author and chair of the Department of Immunology and Microbiology.

August 12, 2022 Other New York

Disclaimer: This story is auto-aggregated by a computer program and is not created or edited by FreshersLIVE.Publisher : IANS-media

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