How virus infection is associated with brain cancer progression

The EBV virus has been found to be widely present in the human population. It usually does not cause any harm, but in some unusual situations such as immunological stress or immunodeficiency the virus can reactivate inside the body. This can further lead to various complications such as a type of blood cancer called Burkitt’s lymphoma, colon cancer and multiple sclerosis.

Previously, studies had provided links to the involvement of EBV in various neurodegenerative diseases. However, how this virus can affect and manipulate brain cells is still unclear.

A research team at IIT Indore used Raman microspectroscopy techniques to explore the potential effects of cancer-causing viruses on brain cells.

The technique based on the Raman effect is a simple, cost-effective tool for finding sensitive chemical changes in biological samples.

The study, published in the journal ACS Chemical Neuroscience, showed that under viral influence there can be timely and gradual changes in various biomolecules in neuronal cells. Additionally, these changes were different than those observed in other supporting brain cells (ie, astrocyte and microglia).

The team found that at times some common biomolecular changes were observed in these cells.

They observed that there was an increase in lipid, cholesterol, proline, and glucose molecules in cells under viral influence, and that these biomolecular entities may ultimately play an important role in the viral capture of cells.

In addition, the study also provided insight into whether these biomolecular changes could be linked to virus-associated effects and to neurological complications.

Dr Hem Chandra Jha, Infection Bioengineering Group at IIT Indore, said, “The research work aids in the understanding of EBV-mediated biomolecular changes in different compartments of the central nervous system, leading to a better understanding of nervous system diseases. “


Disclaimer: This story is auto-aggregated by a computer program and is not created or edited by FreshersLIVE.Publisher : IANS-media

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